PH-D1

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Question 1 of 8

1. Question
Which of the following routes of drug administration ensures 100% bioavailability?
- Oral
- Intramuscular
- Intravenous
- Subcutaneous
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Question 2 of 8

2. Question
Which of the following best defines the Therapeutic Index (TI)?
- The maximum safe dose of a drug
- The ratio of toxic dose to therapeutic dose
- The rate of drug absorption
- The drug concentration at which half-maximal effect is achieved
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Question 3 of 8

3. Question
Which among the following terms are included in pharmacokinetics?
- Absorption
- Therapeutic Index
- Efficacy
- Metabolism
- Distribution
- Potency
- Elimination
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Question 4 of 8

4. Question
Which of the following best defines a full agonist?
- A drug that binds to a receptor and produces maximal biological response
- A drug that binds to a receptor but produces no response
- A drug that reduces the effect of an agonist by binding to a different site
- A drug that competes with the substrate and accelerates receptor degradation
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Question 5 of 8

5. Question
A drug with a very high volume of distribution is most likely to:
- Remain primarily in the plasma
- Be distributed extensively into body tissues
- Be excreted unchanged in urine
- Have a short half-life
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Question 6 of 8

6. Question
Which of the following best describes zero-order kinetics?
- Drug elimination is proportional to its concentration
- Drug is eliminated more rapidly as concentration increases
- A constant amount of drug is eliminated per unit time
- A constant fraction of the drug is eliminated per unit time
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Question 7 of 8

7. Question
Which of the following statements about pharmacokinetics are true?

(Multiple Correct Answers)
- The liver is the primary site for drug metabolism.
- First-pass metabolism can reduce the bioavailability of orally administered drugs.
- Protein binding affects the distribution of a drug in the body.
- Drugs excreted by the kidneys are always reabsorbed in the renal tubules.
- Half-life of a drug depends on both volume of distribution and clearance.
- Bioavailability is higher for oral drugs than for intravenous drugs.
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Question 8 of 8

8. Question
Which of the following is a typical reaction in Phase II metabolism?
- Hydrolysis
- Glucuronidation
- Oxidation
- Reduction
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